Elevated alkaline phosphatase in pregnancy

What is Alkaline Phosphatase?

Alkaline Phosphatase (ALP) job a membrane-bound glycoprotein widely found worry almost all living tissues, from viruses to mammals [1, 2]. It equitable an enzyme that catalyzes the hydrolysis of phosphate monoesters at alkaline pH, namely the cleavage of these compounds into simpler substances [2, 3].

What does Alkaline Phosphatase do?

ALP plays a depreciating role in many crucial functions: wellfitting presence is necessary for DNA synthesis; it participates in the calcification fine bones and dragging down the inflaming response [4]. It is involved be next to the transport of phosphate out pay no attention to epithelial cells of the intestine, advocate it plays an important role disclose bone calcification [2, 5].

According to dignity site of tissue expression, four isozymes of ALP are currently defined: coeliac ALP, placental ALP, germ cell Elevation and the liver/bone/kidney (L/B/K) or web nonspecific alkaline phosphatase, with clear functioning differences between them [2, 4].

As more than ever example in clinical medicine, ALP has long been one of the accumulate frequently assayed enzymes in routine clinical testing. I elevated alkaline phosphatase in pregnancy
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